Ontology highlight
ABSTRACT:
SUBMITTER: Ravasio A
PROVIDER: S-EPMC7411022 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ravasio Andrea A Myaing Myint Z MZ Chia Shumei S Arora Aditya A Sathe Aneesh A Cao Elaine Yiqun EY Bertocchi Cristina C Sharma Ankur A Arasi Bakya B Chung Vin Yee VY Greene Adrienne C AC Tan Tuan Zea TZ Chen Zhongwen Z Ong Hui Ting HT Iyer N Gopalakrishna NG Huang Ruby YunJu RY DasGupta Ramanuj R Groves Jay T JT Viasnoff Virgile V
Communications biology 20200806 1
The Eph family of receptor tyrosine kinases is crucial for assembly and maintenance of healthy tissues. Dysfunction in Eph signaling is causally associated with cancer progression. In breast cancer cells, dysregulated Eph signaling has been linked to alterations in receptor clustering abilities. Here, we implemented a single-cell assay and a scoring scheme to systematically probe the spatial organization of activated EphA receptors in multiple carcinoma cells. We show that cancer cells retain Ep ...[more]