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Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target.


ABSTRACT: In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of cancer. In this review, we describe the function of the HERV-K HML-2 subtype in carcinogenesis as biomarkers, and their potential as targets for cancer immunotherapy.

SUBMITTER: Curty G 

PROVIDER: S-EPMC7412025 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target.

Curty Gislaine G   Marston Jez L JL   de Mulder Rougvie Miguel M   Leal Fabio E FE   Nixon Douglas F DF   Soares Marcelo A MA  

Viruses 20200706 7


In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of c  ...[more]

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2022-08-09 | GSE210662 | GEO