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Accounting for Modeling Errors and Inherent Structural Variability through a Hierarchical Bayesian Model Updating Approach: An Overview.

ABSTRACT: Mechanics-based dynamic models are commonly used in the design and performance assessment of structural systems, and their accuracy can be improved by integrating models with measured data. This paper provides an overview of hierarchical Bayesian model updating which has been recently developed for probabilistic integration of models with measured data, while accounting for different sources of uncertainties and modeling errors. The proposed hierarchical Bayesian framework allows one to explicitly account for pertinent sources of variability such as ambient temperatures and/or excitation amplitudes, as well as modeling errors, and therefore yields more realistic predictions. The paper reports observations from applications of hierarchical approach to three full-scale civil structural systems, namely (1) a footbridge, (2) a 10-story reinforced concrete (RC) building, and (3) a damaged 2-story RC building. The first application highlights the capability of accounting for temperature effects within the hierarchical framework, while the second application underlines the effects of considering bias for prediction error. Finally, the third application considers the effects of excitation amplitude on structural response. The findings underline the importance and capabilities of the hierarchical Bayesian framework for structural identification. Discussions of its advantages and performance over classical deterministic and Bayesian model updating methods are provided.

SUBMITTER: Song M

PROVIDER: S-EPMC7412196 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Accounting for Modeling Errors and Inherent Structural Variability through a Hierarchical Bayesian Model Updating Approach: An Overview.

Song Mingming M Behmanesh Iman I Moaveni Babak B Papadimitriou Costas C

Sensors (Basel, Switzerland) 20200711 14

Mechanics-based dynamic models are commonly used in the design and performance assessment of structural systems, and their accuracy can be improved by integrating models with measured data. This paper provides an overview of hierarchical Bayesian model updating which has been recently developed for probabilistic integration of models with measured data, while accounting for different sources of uncertainties and modeling errors. The proposed hierarchical Bayesian framework allows one to explicit ...[more]

PMID: 32664472

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Project description:To understand how excitable tissues give rise to arrhythmias, it is crucially necessary to understand the electrical dynamics of cells in the context of their environment. Multicellular monolayer cultures have proven useful for investigating arrhythmias and other conduction anomalies, and because of their relatively simple structure, these constructs lend themselves to paired computational studies that often help elucidate mechanisms of the observed behavior. However, tissue cultures of cardiomyocyte monolayers currently require the use of neonatal cells with ionic properties that change rapidly during development and have thus been poorly characterized and modeled to date. Recently, Kirkton and Bursac demonstrated the ability to create biosynthetic excitable tissues from genetically engineered and immortalized HEK293 cells with well-characterized electrical properties and the ability to propagate action potentials. In this study, we developed and validated a computational model of these excitable HEK293 cells (called "Ex293" cells) using existing electrophysiological data and a genetic search algorithm. In order to reproduce not only the mean but also the variability of experimental observations, we examined what sources of variation were required in the computational model. Random cell-to-cell and inter-monolayer variation in both ionic conductances and tissue conductivity was necessary to explain the experimentally observed variability in action potential shape and macroscopic conduction, and the spatial organization of cell-to-cell conductance variation was found to not impact macroscopic behavior; the resulting model accurately reproduces both normal and drug-modified conduction behavior. The development of a computational Ex293 cell and tissue model provides a novel framework to perform paired computational-experimental studies to study normal and abnormal conduction in multidimensional excitable tissue, and the methodology of modeling variation can be applied to models of any excitable cell.

Dataset Information

Accounting for Modeling Errors and Inherent Structural Variability through a Hierarchical Bayesian Model Updating Approach: An Overview.

Publications

Accounting for Modeling Errors and Inherent Structural Variability through a Hierarchical Bayesian Model Updating Approach: An Overview.

Similar Datasets

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