Ontology highlight
ABSTRACT:
SUBMITTER: de Rocquigny H
PROVIDER: S-EPMC7412469 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
de Rocquigny Hugues H Rat Virgile V Pastor Florentin F Darlix Jean Luc JL Hourioux Christophe C Roingeard Philippe P
Viruses 20200708 7
The morphogenesis of Hepatitis B Virus (HBV) viral particles is nucleated by the oligomerization of HBc protein molecules, resulting in the formation of an icosahedral capsid shell containing the replication-competent nucleoprotein complex made of the viral polymerase and the pre-genomic RNA (pgRNA). HBc is a phospho-protein containing two distinct domains acting together throughout the viral replication cycle. The N-terminal domain, (residues 1-140), shown to self-assemble, is linked by a short ...[more]