Ontology highlight
ABSTRACT:
SUBMITTER: Stolz ML
PROVIDER: S-EPMC7412551 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral ...[more]