Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC7413381 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Guo Chuang C Li Bin B Ma Huan H Wang Xiaofang X Cai Pengfei P Yu Qiaoni Q Zhu Lin L Jin Liying L Jiang Chen C Fang Jingwen J Liu Qian Q Zong Dandan D Zhang Wen W Lu Yichen Y Li Kun K Gao Xuyuan X Fu Binqing B Liu Lianxin L Ma Xiaoling X Weng Jianping J Wei Haiming H Jin Tengchuan T Lin Jun J Qu Kun K
Nature communications 20200806 1
Several studies show that the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of the immune cell composition of two severe-stage COVID-19 patients prior to and following tocilizumab-induced remission, we identify a monocyte subpopulation that contributes to the inflammatory cytokine storms. Furthermore, although tocilizumab tr ...[more]