Ontology highlight
ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC7413384 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gao Xiao X Wang Qingwei Q Wang Ying Y Liu Jiang J Liu Shuang S Liu Jian J Zhou Xingli X Zhou Li L Chen Hui H Pan Linian L Chen Jiwei J Wang Da D Zhang Qing Q Shen Shihui S Xiao Yu Y Wu Zhipeng Z Cheng Yiyun Y Chen Geng G Kubra Syeda S Qin Jun J Huang Lan L Zhang Pei P Wang Chuangui C Moses Robb E RE Lonard David M DM Malley Bert W O' BWO Fares Fuad F Zhang Bianhong B Li Xiaotao X Li Lei L Xiao Jianru J
Nature communications 20200806 1
A major challenge in chemotherapy is chemotherapy resistance in cells lacking p53. Here we demonstrate that NIP30, an inhibitor of the oncogenic REGγ-proteasome, attenuates cancer cell growth and sensitizes p53-compromised cells to chemotherapeutic agents. NIP30 acts by binding to REGγ via an evolutionarily-conserved serine-rich domain with 4-serine phosphorylation. We find the cyclin-dependent phosphatase CDC25A is a key regulator for NIP30 phosphorylation and modulation of REGγ activity during ...[more]