Ontology highlight
ABSTRACT:
SUBMITTER: Noreng S
PROVIDER: S-EPMC7413742 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Noreng Sigrid S Posert Richard R Bharadwaj Arpita A Houser Alexandra A Baconguis Isabelle I
eLife 20200730
The molecular bases of heteromeric assembly and link between Na<sup>+</sup> self-inhibition and protease-sensitivity in epithelial sodium channels (ENaCs) are not fully understood. Previously, we demonstrated that ENaC subunits - α, β, and γ - assemble in a counterclockwise configuration when viewed from outside the cell with the protease-sensitive GRIP domains in the periphery (Noreng et al., 2018). Here we describe the structure of ENaC resolved by cryo-electron microscopy at 3 Å. We find that ...[more]