Ontology highlight
ABSTRACT:
SUBMITTER: Smith TC
PROVIDER: S-EPMC7414088 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Smith Trever C TC Pullen Krista M KM Olson Michaela C MC McNellis Morgan E ME Richardson Ian I Hu Sophia S Larkins-Ford Jonah J Wang Xin X Freundlich Joel S JS Ando D Michael DM Aldridge Bree B BB
Proceedings of the National Academy of Sciences of the United States of America 20200717 31
Morphological profiling is a method to classify target pathways of antibacterials based on how bacteria respond to treatment through changes to cellular shape and spatial organization. Here we utilized the cell-to-cell variation in morphological features of <i>Mycobacterium tuberculosis</i> bacilli to develop a rapid profiling platform called Morphological Evaluation and Understanding of Stress (MorphEUS). MorphEUS classified 94% of tested drugs correctly into broad categories according to modes ...[more]