Ontology highlight
ABSTRACT:
SUBMITTER: Ren W
PROVIDER: S-EPMC7414182 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ren Wendan W Fan Huitao H Grimm Sara A SA Guo Yiran Y Kim Jae Jin JJ Yin Jiekai J Li Linhui L Petell Christopher J CJ Tan Xiao-Feng XF Zhang Zhi-Min ZM Coan John P JP Gao Linfeng L Cai Ling L Detrick Brittany B Çetin Burak B Cui Qiang Q Strahl Brian D BD Gozani Or O Wang Yinsheng Y Miller Kyle M KM O'Leary Seán E SE Wade Paul A PA Patel Dinshaw J DJ Wang Gang Greg GG Song Jikui J
Proceedings of the National Academy of Sciences of the United States of America 20200716 31
In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced chromatin state. However, it remains elusive how these epigenetic modifications crosstalk. Here, through structural and biochemical characterizations, we identified the replication foci targeting sequence (RFTS) domain of maintenance DNA methyltransferase DNMT1, a module known to bind the ubiquitylated H3 (H3Ub), as a spec ...[more]