HIF-1? suppresses myeloma progression by targeting Mcl-1.
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ABSTRACT:
SUBMITTER: Wu F
PROVIDER: S-EPMC7414501 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
HIF-1α suppresses myeloma progression by targeting Mcl-1.
Wu Feng F Tong Dong-Dong DD Ni Lei L Wang Lu-Min LM Wang Meng-Chang MC
International journal of clinical and experimental pathology 20200701 7
HIF-1α is involved in the carcinogenesis and progression of multiple types of cancer. However, the precise role of HIF-1α is unclear in multiple myeloma. Through the qRT-PCR and CCK-8 assays, we demonstrated that silencing the expression of HIF-1α and Mcl-1, MM proliferation can be decreased and apoptosis can be induced. Next, using the GEO database, we found that Mcl-1 was increased in MMs. Mcl-1 overexpression counterbalanced the tumor suppressing effect of siHIF-1α on MM apoptosis. Additional ...[more]
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