Ontology highlight
ABSTRACT:
SUBMITTER: de Luca XM
PROVIDER: S-EPMC7414867 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
de Luca Xavier M XM Newell Felicity F Kazakoff Stephen H SH Hartel Gunter G McCart Reed Amy E AE Holmes Oliver O Xu Qinying Q Wood Scott S Leonard Conrad C Pearson John V JV Lakhani Sunil R SR Waddell Nicola N Nones Katia K Simpson Peter T PT
NPJ breast cancer 20200807
The homologous recombination deficiency (HRD) score was developed using whole-genome copy number data derived from arrays as a way to infer deficiency in the homologous recombination DNA damage repair pathway (in particular <i>BRCA1</i> or <i>BRCA2</i> deficiency) in breast cancer samples. The score has utility in understanding tumour biology and may be indicative of response to certain therapeutic strategies. Studies have used whole-exome sequencing to derive the HRD score, however, with increa ...[more]