Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-? pathway.
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ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC7415001 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-β pathway.
Liu Wei W Sun Yanfeng Y Dong Xiaohui X Yin Qi Q Zhu Huimin H Li Siwei S Zhou Jin J Wang Changyong C
Regenerative biomaterials 20200424 4
The cell-derived extracellular matrix (ECM)-modified scaffolds have advantages of mimic tissue specificity and been thought to better mimic the native cellular microenvironment <i>in vitro</i>. ECM derived from cardiac fibroblasts (CFs) are considered as key elements that provide a natural cell growth microenvironment and change the fate of cardiomyocytes (CMs). Here, a new hybrid scaffold is designed based on silk fibroin (SF) scaffold and CFs-derived ECM. CFs were seeded on the SF scaffold for ...[more]
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