Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes.
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ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC7415089 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes.
Sun Lin L Xi Shugang S He Guangyu G Li Zhuo Z Gang Xiaokun X Sun Chenglin C Guo Weiying W Wang Guixia G
Journal of diabetes research 20200730
Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic <i>β</i>-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 <sup><b>+</b></sup> and CD8 <sup><b>+</b></sup> T-cells, as well as other T-cell subsets, could affect onset of autoimmunity. Furthermore, cells involved in innate immunity, including the macrophages, dendritic cells, and natural killer (NK ...[more]
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