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Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.

ABSTRACT: Purpose:We examined inferior oblique muscles from subjects with over-elevation in adduction for characteristics that might shed light on the potential mechanisms for their abnormal eye position. Methods:The inferior oblique muscles were obtained at the time of surgery in subjects diagnosed with either primary inferior oblique overaction or Apert syndrome. The muscles were frozen and processed for morphometric analysis of myofiber size, central nucleation, myosin heavy chain (MyHC) isoform expression, nerve density, and numbers of neuromuscular junctions per muscle section. Results:The inferior oblique muscles from subjects with Apert Syndrome were smaller, and had a much more heterogeneous profile relative to myofiber cross-sectional area compared to controls. Increased central nucleation in the Apert syndrome muscles suggested on-going myofiber regeneration or reinnervation over time. Complex changes were seen in the MyHC isoform patterns that would predict slower and more sustained contractions than in the control muscles. Nerve fiber densities were significantly increased compared to controls for the muscles with primary inferior oblique overaction and Apert syndrome that had no prior surgery. The muscles from Apert syndrome subjects as well as those with primary inferior oblique overaction with no prior surgery had significantly elevated numbers of neuromuscular junctions relative to the whole muscle area. Conclusions:The muscles from both sets of subjects were significantly different from control muscles in a number of properties examined. These data support the view that despite similar manifestations of eye misalignment, the potential mechanism behind the strabismus in these subjects is significantly different.

SUBMITTER: Rudell JC

PROVIDER: S-EPMC7415317 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.

Rudell Jolene C JC Stager David D Felius Joost J McLoon Linda K LK

Investigative ophthalmology & visual science 20200601 6

<h4>Purpose</h4>We examined inferior oblique muscles from subjects with over-elevation in adduction for characteristics that might shed light on the potential mechanisms for their abnormal eye position.<h4>Methods</h4>The inferior oblique muscles were obtained at the time of surgery in subjects diagnosed with either primary inferior oblique overaction or Apert syndrome. The muscles were frozen and processed for morphometric analysis of myofiber size, central nucleation, myosin heavy chain (MyHC) ...[more]

PMID: 32539136

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Project description:The importance of an interaction between trunk stability muscles and hip muscle function has been suggested. However, reported exercises rarely act on the trunk and hip muscles simultaneously. Here, we devised an abdominal oblique and hip muscle exercise, the Self-oblique exercise (SOE). We examined whether SOE activated abdominal and hip muscles in the supine and half-kneeling positions, compared with abdominal crunch (AC) and plank exercises; and whether participants could modulate the exercise load. Participants were 20 healthy males with some sports experience such as football and baseball on average 10.5 ± 4.0 years. Participants applied self-pressure to their right thighs using the contralateral upper limb with 40% or 70% of the maximum force in Supine SOE and Half- kneeling SOE. The following abdominal and hip muscles were measured using surface electromyography: bilateral external obliques (EO), bilateral internal obliques (IO), right rectus abdominis, right gluteus medius (GMed), and right adductor longus (ADD). All evaluated muscle groups showed significant differences between exercises (p < 0.001). Supine SOE-70% showed 80.4% maximal voluntary contraction (MVC) for left EO (p < 0.017), 61.4% MVC for right IO (p < 0.027), 24.3% MVC for GMed (p < 0.002), and 42.4% MVC for ADD (p < 0.004); these were significantly greatest among all exercises. Muscle activity during Supine SOE-70% was greater than that during Supine SOE-40%. Similarly, Half-kneeling SOE-40% promoted abdominal and hip muscle exertion, and showed more significant activity in GMed (p < 0.006) and ADD (p < 0.001) than AC and plank. SOE could activate abdominal and hip muscles depends on the pressure applied by upper limb. Also, SOE allows participants to modulate the exercise load in a self-controlled step by step manner. Modulation of the exercise load is difficult in AC or plank compared to SOE, and AC or plank cannot obtain simultaneous oblique and hip muscle activity. SOE could be practiced anywhere, in various positions, without any tools.

Dataset Information

Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.

Publications

Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.

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