Hitchhiking of Viral Genomes on Cellular Chromosomes.
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ABSTRACT:
SUBMITTER: Coursey TL
PROVIDER: S-EPMC7415349 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Hitchhiking of Viral Genomes on Cellular Chromosomes.
Coursey Tami L TL McBride Alison A AA
Annual review of virology 20190705 1
Persistent viral infections require a host cell reservoir that maintains functional copies of the viral genome. To this end, several DNA viruses maintain their genomes as extrachromosomal DNA minichromosomes in actively dividing cells. These viruses typically encode a viral protein that binds specifically to viral DNA genomes and tethers them to host mitotic chromosomes, thus enabling the viral genomes to hitchhike or piggyback into daughter cells. Viruses that use this tethering mechanism inclu ...[more]
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