Ontology highlight
ABSTRACT:
SUBMITTER: Nandi S
PROVIDER: S-EPMC7415593 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Nandi Seema S Sommerville Laura L Nellenbach Kimberly K Mihalko Emily E Erb Mary M Freytes Donald O DO Hoffman Maureane M Monroe Dougald D Brown Ashley C AC
Journal of colloid and interface science 20200526
Following injury, a fibrin-rich provisional matrix is formed to stem blood loss and provide a scaffold for infiltrating cells, which rebuild the damaged tissue. Defects in fibrin network formation contribute to impaired healing outcomes, as evidenced in hemophilia. Platelet-fibrin interactions greatly influence fibrin network structure via clot contraction, which increases fibrin density over time. Previously developed hemostatic platelet-like particles (PLPs) are capable of mimicking platelet f ...[more]