Ontology highlight
ABSTRACT:
SUBMITTER: Grosswendt S
PROVIDER: S-EPMC7415732 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Grosswendt Stefanie S Kretzmer Helene H Smith Zachary D ZD Kumar Abhishek Sampath AS Hetzel Sara S Wittler Lars L Klages Sven S Timmermann Bernd B Mukherji Shankar S Meissner Alexander A
Nature 20200729 7819
During ontogeny, proliferating cells become restricted in their fate through the combined action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which recognizes universally available histone residues or nucleotides in a context-dependent manner<sup>1,2</sup>. The molecular functions of these regulators are generally well understood, but assigning direct developmental roles to them is hampered by complex mutant phenotypes that often emerge after gastrulation<sup> ...[more]