Investigation of the evolution of radiation-induced lung damage using serial CT imaging and pulmonary function tests.

ABSTRACT:

Background and purpose

Radiation-induced lung damage (RILD) is a common consequence of lung cancer radiotherapy (RT) with unclear evolution over time. We quantify radiological RILD longitudinally and correlate it with dosimetry and respiratory morbidity.

Materials and methods

CTs were available pre-RT and at 3, 6, 12 and 24-months post-RT for forty-five subjects enrolled in a phase 1/2 clinical trial of isotoxic, dose-escalated chemoradiotherapy for locally advanced non-small cell lung cancer. Fifteen CT-based measures of parenchymal, pleural and lung volume change, and anatomical distortions, were calculated. Respiratory morbidity was assessed with the Medical Research Council (MRC) dyspnoea score and spirometric pulmonary function tests (PFTs): FVC, FEV₁, FEV

SUBMITTER: Veiga C 

PROVIDER: S-EPMC7416106 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature