Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7416259 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Ying Y Cui Xinyue X Gao Ming-Qing MQ Xue Meilan M Xu Hongwei H Chang Zhishang Z Jiang Yushan Y Liang Hui H
Mediators of inflammation 20200801
Aplysin is a brominated sesquiterpene with an isoprene skeleton and has biological activities. The purpose of this study is to investigate the inhibitory effect of aplysin on spontaneous pancreatic necrosis in nonobese diabetic (NOD) mice and its potential mechanisms. Results showed that NOD mice at 12 weeks of age showed obvious spontaneous pancreatic necrosis, damaged tight junctions of intestinal epithelia, and widened gaps in tight and adherens junctions. Aplysin intervention was able to all ...[more]