Ontology highlight
ABSTRACT:
SUBMITTER: Oizel K
PROVIDER: S-EPMC7416393 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Oizel Kristell K Yang Chendong C Renoult Ophelie O Gautier Fabien F Do Quyen N QN Joalland Noemie N Gao Xiaofei X Ko Bookyung B Vallette François F Ge Woo-Ping WP Paris François F DeBerardinis Ralph J RJ Pecqueur Claire C
Cancer & metabolism 20200810
<h4>Background</h4>Glioblastoma (GBM) are highly heterogeneous on the cellular and molecular basis. It has been proposed that glutamine metabolism of primary cells established from human tumors discriminates aggressive mesenchymal GBM subtype to other subtypes.<h4>Methods</h4>To study glutamine metabolism in vivo, we used a human orthotopic mouse model for GBM. Tumors evolving from the implanted primary GBM cells expressing different molecular signatures were analyzed using mass spectrometry for ...[more]