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Genome sequence of the progenitor of the wheat D genome Aegilops tauschii.


ABSTRACT: Aegilops tauschii is the diploid progenitor of the D genome of hexaploid wheat (Triticum aestivum, genomes AABBDD) and an important genetic resource for wheat. The large size and highly repetitive nature of the Ae. tauschii genome has until now precluded the development of a reference-quality genome sequence. Here we use an array of advanced technologies, including ordered-clone genome sequencing, whole-genome shotgun sequencing, and BioNano optical genome mapping, to generate a reference-quality genome sequence for Ae. tauschii ssp. strangulata accession AL8/78, which is closely related to the wheat D genome. We show that compared to other sequenced plant genomes, including a much larger conifer genome, the Ae. tauschii genome contains unprecedented amounts of very similar repeated sequences. Our genome comparisons reveal that the Ae. tauschii genome has a greater number of dispersed duplicated genes than other sequenced genomes and its chromosomes have been structurally evolving an order of magnitude faster than those of other grass genomes. The decay of colinearity with other grass genomes correlates with recombination rates along chromosomes. We propose that the vast amounts of very similar repeated sequences cause frequent errors in recombination and lead to gene duplications and structural chromosome changes that drive fast genome evolution.

SUBMITTER: Luo MC 

PROVIDER: S-EPMC7416625 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Genome sequence of the progenitor of the wheat D genome Aegilops tauschii.

Luo Ming-Cheng MC   Gu Yong Q YQ   Puiu Daniela D   Wang Hao H   Twardziok Sven O SO   Deal Karin R KR   Huo Naxin N   Zhu Tingting T   Wang Le L   Wang Yi Y   McGuire Patrick E PE   Liu Shuyang S   Long Hai H   Ramasamy Ramesh K RK   Rodriguez Juan C JC   Van Sonny L SL   Yuan Luxia L   Wang Zhenzhong Z   Xia Zhiqiang Z   Xiao Lichan L   Anderson Olin D OD   Ouyang Shuhong S   Liang Yong Y   Zimin Aleksey V AV   Pertea Geo G   Qi Peng P   Bennetzen Jeffrey L JL   Dai Xiongtao X   Dawson Matthew W MW   Müller Hans-Georg HG   Kugler Karl K   Rivarola-Duarte Lorena L   Spannagl Manuel M   Mayer Klaus F X KFX   Lu Fu-Hao FH   Bevan Michael W MW   Leroy Philippe P   Li Pingchuan P   You Frank M FM   Sun Qixin Q   Liu Zhiyong Z   Lyons Eric E   Wicker Thomas T   Salzberg Steven L SL   Devos Katrien M KM   Dvořák Jan J  

Nature 20171115 7681


Aegilops tauschii is the diploid progenitor of the D genome of hexaploid wheat (Triticum aestivum, genomes AABBDD) and an important genetic resource for wheat. The large size and highly repetitive nature of the Ae. tauschii genome has until now precluded the development of a reference-quality genome sequence. Here we use an array of advanced technologies, including ordered-clone genome sequencing, whole-genome shotgun sequencing, and BioNano optical genome mapping, to generate a reference-qualit  ...[more]

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