Ontology highlight
ABSTRACT:
SUBMITTER: Zhang D
PROVIDER: S-EPMC7417721 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zhang Dan D Fan Rong R Lei Li L Lei Lei L Wang Yanmeng Y Lv Nan N Chen Ping P Williamson Ramone A RA Wang Baiyan B Hu Jinsong J
Journal of cellular and molecular medicine 20200706 16
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into a variety of cell types. Bortezomib, the first approved proteasome inhibitor used for the treatment of multiple myeloma (MM), has been shown to induce osteoblast differentiation, making it beneficial for myeloma bone disease. In the present study, we aimed to investigate the effects and underlying mechanisms of bortezomib on the cell cycle during osteogenic differentiation. We confirmed that low doses of bortezom ...[more]