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Ritonavir associated maculopathy- multimodal imaging and electrophysiology findings.

ABSTRACT: Purpose:To report the case 47-year-old patient presenting with severe maculopathy associated with long-term ritonavir treatment. Methods:Observational case report of one patient and literature review. Results:A 47 year-old Caucasian man presented with progressive bilateral vision loss for the past 5 years. His medical history included Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) coinfection since 1992. He was treated by highly active antiretroviral therapy for 24 years including 4 years of didanosine treatment and 18 years of ritonavir treatment. Bilateral extensive macular atrophy with foveal sparing on the left eye and absence of midperipheral/peripheral retina involvement was confirmed on multimodal imaging and functional testing including swept-source OCT angiography and electroretinography. Conclusion:Ritonavir associated maculopathy is a scarcely described medication-associated retinopathy. In this case, an extensive macular atrophy (with complete loss of photoreceptor, RPE and choriocapillaris layers) and subsequent cone-rod dysfunction appeared after 18 years of ritonavir exposure.

SUBMITTER: Bunod R

PROVIDER: S-EPMC7417746 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Ritonavir associated maculopathy- multimodal imaging and electrophysiology findings.

Bunod Roxane R Miere Alexandra A Zambrowski Olivia O Girard Pierre-Marie PM Surgers Laure L Souied Eric H EH

American journal of ophthalmology case reports 20200722

<h4>Purpose</h4>To report the case 47-year-old patient presenting with severe maculopathy associated with long-term ritonavir treatment.<h4>Methods</h4>Observational case report of one patient and literature review.<h4>Results</h4>A 47 year-old Caucasian man presented with progressive bilateral vision loss for the past 5 years. His medical history included Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) coinfection since 1992. He was treated by highly active antiretroviral therapy ...[more]

PMID: 32803017

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Dataset Information

Ritonavir associated maculopathy- multimodal imaging and electrophysiology findings.

Publications

Ritonavir associated maculopathy- multimodal imaging and electrophysiology findings.

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