Unknown

Dataset Information

0

Synthesis and Biological Evaluation of Thio-Derivatives of 2-Hydroxy-1,4-Naphthoquinone (Lawsone) as Novel Antiplatelet Agents.


ABSTRACT: We designed and synthesized in water, using conventional heating and microwave irradiation, new thio-derivatives of 2-hydroxy-1,4-naphthoquinone, a naturally occurring pigment known as lawsone or hennotannic acid, thus improving their antiplatelet activity with relevance to their potential future use in thrombus formation treatment. The structure-activity relationship showed that the thiophenyl moiety enhances the antiplatelet activity. Moreover, the position and nature of the substituent at the phenyl ring have a key effect on the observed biological activity. Compound 4 (2-((4-bromophenyl)thio)-3-hydroxynaphthalene-1,4-dione) was the most active derivative, presenting IC50 values for platelet aggregation inhibition of 15.03 ± 1.52 ?M for TRAP-6, and 5.58 ± 1.01 ?M for collagen. Importantly, no cytotoxicity was observed. Finally, we discussed the structure-activity relationships of these new lawsone thio-derivatives on inhibition of TRAP-6- and collagen-induced platelet aggregation.

SUBMITTER: Monroy-Cardenas M 

PROVIDER: S-EPMC7417813 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Synthesis and Biological Evaluation of Thio-Derivatives of 2-Hydroxy-1,4-Naphthoquinone (Lawsone) as Novel Antiplatelet Agents.

Monroy-Cárdenas Matías M   Méndez Diego D   Trostchansky Andrés A   Martínez-Cifuentes Maximiliano M   Araya-Maturana Ramiro R   Fuentes Eduardo E  

Frontiers in chemistry 20200804


We designed and synthesized in water, using conventional heating and microwave irradiation, new thio-derivatives of 2-hydroxy-1,4-naphthoquinone, a naturally occurring pigment known as lawsone or hennotannic acid, thus improving their antiplatelet activity with relevance to their potential future use in thrombus formation treatment. The structure-activity relationship showed that the thiophenyl moiety enhances the antiplatelet activity. Moreover, the position and nature of the substituent at the  ...[more]

Similar Datasets

| S-EPMC8509387 | biostudies-literature
| S-EPMC6507621 | biostudies-literature
| S-EPMC4056940 | biostudies-literature
| S-EPMC6331847 | biostudies-other
| S-EPMC5617738 | biostudies-literature
| S-EPMC6445160 | biostudies-literature
| S-EPMC5533781 | biostudies-literature
| S-EPMC8372213 | biostudies-literature
| S-EPMC4804716 | biostudies-literature
| S-EPMC4076656 | biostudies-literature