Ontology highlight
ABSTRACT:
SUBMITTER: Monroy-Cardenas M
PROVIDER: S-EPMC7417813 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Monroy-Cárdenas Matías M Méndez Diego D Trostchansky Andrés A Martínez-Cifuentes Maximiliano M Araya-Maturana Ramiro R Fuentes Eduardo E
Frontiers in chemistry 20200804
We designed and synthesized in water, using conventional heating and microwave irradiation, new thio-derivatives of 2-hydroxy-1,4-naphthoquinone, a naturally occurring pigment known as lawsone or hennotannic acid, thus improving their antiplatelet activity with relevance to their potential future use in thrombus formation treatment. The structure-activity relationship showed that the thiophenyl moiety enhances the antiplatelet activity. Moreover, the position and nature of the substituent at the ...[more]