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Copper-Catalyzed Modular Assembly of Polyheterocycles.

ABSTRACT: Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.

SUBMITTER: Wang Q

PROVIDER: S-EPMC7418108 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Copper-Catalyzed Modular Assembly of Polyheterocycles.

Wang Qian Q Tuinhof Jesse J Mgimpatsang Kumchok C KC Kurpiewska Katarzyna K Kalinowska-Tluscik Justyna J Dömling Alexander A

The Journal of organic chemistry 20200712 15

Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-<i>c</i>]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps. ...[more]

PMID: 32615764

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