Ontology highlight
ABSTRACT:
SUBMITTER: Houlahan KE
PROVIDER: S-EPMC7418214 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature medicine 20191007 10
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms on the somatic epigenome of 589 localized prostate tumors. Predisposition risk loci influence a tumor's epigenome, uncovering a mechanism for cancer susceptibility. We identified and validated 1,178 loci associated with altered methylation in tumoral but not nonmalignant tissue. The ...[more]