Ontology highlight
ABSTRACT:
SUBMITTER: Nakatsuka N
PROVIDER: S-EPMC7418405 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nakatsuka Nathan N Harney Éadaoin É Mallick Swapan S Mah Matthew M Patterson Nick N Reich David D
Genome biology 20200810 1
We report a method called ContamLD for estimating autosomal ancient DNA (aDNA) contamination by measuring the breakdown of linkage disequilibrium in a sequenced individual due to the introduction of contaminant DNA. ContamLD leverages the idea that contaminants should have haplotypes uncorrelated to those of the studied individual. Using simulated data, we confirm that ContamLD accurately infers contamination rates with low standard errors: for example, less than 1.5% standard error in cases wit ...[more]