Ontology highlight
ABSTRACT:
SUBMITTER: Garate-Carrillo A
PROVIDER: S-EPMC7418791 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Garate-Carrillo Alejandra A Navarrete-Yañez Viridiana V Ortiz-Vilchis Pilar P Guevara Gustavo G Castillo Carmen C Mendoza-Lorenzo Patricia P Ceballos Guillermo G Ortiz-Flores Miguel M Najera Nayelli N Bustamante-Pozo Moises Muratt MM Rubio-Gayosso Ivan I Villarreal Francisco F Ramirez-Sanchez Israel I
European journal of pharmacology 20200811
Endothelial dysfunction (EnD) occurs with aging and endothelial nitric oxide (NO) production by NO synthase (NOS) can be impaired. Low NO levels have been linked to increased arginase (Ar) activity as Ar competes with NOS for L-arginine. The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in silico modeling we demonstrate that Epi interacts with Ar similarly to its inhibitor Norvaline (Norv). Using in vitro and in vivo m ...[more]