Advances in oligonucleotide drug delivery.
Ontology highlight
ABSTRACT:
SUBMITTER: Roberts TC
PROVIDER: S-EPMC7419031 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Advances in oligonucleotide drug delivery.
Roberts Thomas C TC Langer Robert R Wood Matthew J A MJA
Nature reviews. Drug discovery 20200811 10
Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing. As such, these molecules have potential therapeutic applications for myriad indications, with several oligonucleotide drugs recently gaining approval. However, despite recent technological advances, achieving efficient oligonucleotide delivery, particularly to ...[more]
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