Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study.

ABSTRACT: OBJECTIVE:The sulfur amino acid (SAA) cysteine is positively related, whereas polyunsaturated fatty acids (PUFAs) are inversely related to activity of the lipogenic enzyme stearoyl-CoA desaturase (SCD). High SCD activity promotes obesity in animals, and plasma activity indices positively associates with fat mass in humans. SCD may thus be a target for dietary intervention with SAA restriction and PUFA enrichment with unknown potential benefits for body composition. We randomized ten healthy individuals to a meal restricted in SAAs and enriched with PUFAs (Cys/Metlow?+?PUFA) (n?=?5) or a meal enriched in SAA and saturated fatty acids (Cys/Methigh?+?SFA) (n?=?5). We measured plasma SCD activity indices (SCD16 and SCD18) and SAAs response hourly from baseline and up to 4 h postprandial. RESULTS:SCD16 was unchanged whereas SCD18 tended to increase in the Cys/Metlow?+?PUFA compared to the Cys/Methigh?+?SFA group (ptime*group interaction?=?0.08). Plasma concentrations of total cysteine fractions including free and reduced cysteine decreased in the Cys/Metlow?+?PUFA compared to the Cys/Methigh?+?SFA group (both ptime*group interaction?

SUBMITTER: Olsen T 

PROVIDER: S-EPMC7419218 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature