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Prognostic value of a five-lncRNA signature in esophageal squamous cell carcinoma.


ABSTRACT: Background:The aim of this study was to identify prognostic long non-coding RNAs (lncRNAs) and develop a multi-lncRNA signature for suvival prediction in esophageal squamous cell carcinoma (ESCC). Methods:The clinical and gene expression data from Gene Expression Omnibus database (GSE53624, n?=?119) were obtianed as training set. A total of 98 paired ESCC tumor and normal tissues were detected by RNA sequencing and used as test set. Another 84 ESCC tissues were used for real-time quantitative PCR(qRT-PCR) and as an independent validation cohort. Survival analysis, Cox regression and Kaplan-Meier analysis were performed. Results:We screened a prognostic marker of ESCC from the GSE53624 dataset and named it as the five-lncRNA signature including AC007179.1, MORF4L2-AS1, RP11-488I20.9, RP13-30A9.2, RP4-735C1.6, which could classify patients into high- and low-risk groups with significantly different survival(median survival: 1.75 years vs. 4.01 years, log rank P?

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7419219 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Prognostic value of a five-lncRNA signature in esophageal squamous cell carcinoma.

Zhang Lan L   Li Pan P   Liu Enjie E   Xing Chenju C   Zhu Di D   Zhang Jianying J   Wang Weiwei W   Jiang Guozhong G  

Cancer cell international 20200810


<h4>Background</h4>The aim of this study was to identify prognostic long non-coding RNAs (lncRNAs) and develop a multi-lncRNA signature for suvival prediction in esophageal squamous cell carcinoma (ESCC).<h4>Methods</h4>The clinical and gene expression data from Gene Expression Omnibus database (GSE53624, n = 119) were obtianed as training set. A total of 98 paired ESCC tumor and normal tissues were detected by RNA sequencing and used as test set. Another 84 ESCC tissues were used for real-time  ...[more]

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