Ontology highlight
ABSTRACT:
SUBMITTER: Mi B
PROVIDER: S-EPMC7419275 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mi Bobin B Yan Chenchen C Xue Hang H Chen Lang L Panayi Adriana C AC Hu Liangcong L Hu Yiqiang Y Cao Faqi F Sun Yun Y Zhou Wu W Xiong Yuan Y Liu Guohui G
Molecular therapy. Nucleic acids 20200723
Mesenchymal stem cells (MSCs) critically contribute to bone formation, and proper induction of osteogenic differentiation can lead to an increase in bone mass. In the present study, we reported that an increased miR-194-5p level in plasma is inversely related to the degree of bone formation in osteoporosis patients. We also noted that increased miR-194-5p in the MSCs of ovariectomized (OVX) mice and agomiR-194-5p manipulation of miR-194-5p significantly suppressed bone formation, both in aged an ...[more]