Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest.

ABSTRACT: PURPOSE:To compare endocrine responses to intermittent vs continuous enteral nutrition provision during short-term bed rest. METHODS:Twenty healthy men underwent 7 days of bed rest, during which they were randomized to receive enteral nutrition (47%E as carbohydrate, 34%E as fat, 16%E as protein and 3%E as fibre) in a continuous (CONTINUOUS; n?=?10; 24 h day-1 at a constant rate) or intermittent (INTERMITTENT; n?=?10; as 4 meals per day separated by 5 h) pattern. Daily plasma samples were taken every morning to assess metabolite/hormone concentrations. RESULTS:During bed rest, plasma leptin concentrations were elevated to a lesser extent with INTERMITTENT vs CONTINUOUS (iAUC: 0.42?±?0.38 vs 0.95?±?0.48 nmol L-1, respectively; P?=?0.014) as were insulin concentrations (interaction effect, P?

SUBMITTER: Gonzalez JT 

PROVIDER: S-EPMC7419443 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature