Ontology highlight
ABSTRACT:
SUBMITTER: Kim HK
PROVIDER: S-EPMC7419509 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Kim Hyun-Kyoung HK Bhattarai Kashi Raj KR Junjappa Raghu Patil RP Ahn Jin Hee JH Pagire Suvarna H SH Yoo Hyun Ju HJ Han Jaeseok J Lee Duckgue D Kim Kyung-Woon KW Kim Hyung-Ryong HR Chae Han-Jung HJ
Nature communications 20200811 1
Transmembrane B cell lymphoma 2-associated X protein inhibitor motif-containing (TMBIM) 6, a Ca<sup>2+</sup> channel-like protein, is highly up-regulated in several cancer types. Here, we show that TMBIM6 is closely associated with survival in patients with cervical, breast, lung, and prostate cancer. TMBIM6 deletion or knockdown suppresses primary tumor growth. Further, mTORC2 activation is up-regulated by TMBIM6 and stimulates glycolysis, protein synthesis, and the expression of lipid synthesi ...[more]