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Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior.

ABSTRACT: Perception reflects not only sensory inputs, but also the endogenous state when these inputs enter the brain. Prior studies show that endogenous neural states influence stimulus processing through non-specific, global mechanisms, such as spontaneous fluctuations of arousal. It is unclear if endogenous activity influences circuit and stimulus-specific processing and behavior as well. Here we use intracranial recordings from 30 pre-surgical epilepsy patients to show that patterns of endogenous activity are related to the strength of trial-by-trial neural tuning in different visual category-selective neural circuits. The same aspects of the endogenous activity that relate to tuning in a particular neural circuit also correlate to behavioral reaction times only for stimuli from the category that circuit is selective for. These results suggest that endogenous activity can modulate neural tuning and influence behavior in a circuit- and stimulus-specific manner, reflecting a potential mechanism by which endogenous neural states facilitate and bias perception.

SUBMITTER: Li Y

PROVIDER: S-EPMC7419548 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior.

Li Yuanning Y Ward Michael J MJ Richardson R Mark RM G'Sell Max M Ghuman Avniel Singh AS

Nature communications 20200811 1

Perception reflects not only sensory inputs, but also the endogenous state when these inputs enter the brain. Prior studies show that endogenous neural states influence stimulus processing through non-specific, global mechanisms, such as spontaneous fluctuations of arousal. It is unclear if endogenous activity influences circuit and stimulus-specific processing and behavior as well. Here we use intracranial recordings from 30 pre-surgical epilepsy patients to show that patterns of endogenous act ...[more]

PMID: 32782303

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Dataset Information

Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior.

Publications

Endogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior.

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