Ontology highlight
ABSTRACT:
SUBMITTER: Abay-Norgaard S
PROVIDER: S-EPMC7420840 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Abay-Nørgaard Steffen S Attianese Benedetta B Boreggio Laura L Salcini Anna Elisabetta AE
Development (Cambridge, England) 20200807 15
Post-translational histone modifications regulate chromatin compaction and gene expression to control many aspects of development. Mutations in genes encoding regulators of H3K4 methylation are causally associated with neurodevelopmental disorders characterized by intellectual disability and deficits in motor functions. However, it remains unclear how H3K4 methylation influences nervous system development and contributes to the aetiology of disease. Here, we show that the catalytic activity of < ...[more]