Ontology highlight
ABSTRACT:
SUBMITTER: Elvsashagen T
PROVIDER: S-EPMC7421944 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Elvsåshagen Torbjørn T Bahrami Shahram S van der Meer Dennis D Agartz Ingrid I Alnæs Dag D Barch Deanna M DM Baur-Streubel Ramona R Bertolino Alessandro A Beyer Mona K MK Blasi Giuseppe G Borgwardt Stefan S Boye Birgitte B Buitelaar Jan J Bøen Erlend E Celius Elisabeth Gulowsen EG Cervenka Simon S Conzelmann Annette A Coynel David D Di Carlo Pasquale P Djurovic Srdjan S Eisenacher Sarah S Espeseth Thomas T Fatouros-Bergman Helena H Flyckt Lena L Franke Barbara B Frei Oleksandr O Gelao Barbara B Harbo Hanne Flinstad HF Hartman Catharina A CA Håberg Asta A Heslenfeld Dirk D Hoekstra Pieter J PJ Høgestøl Einar A EA Jonassen Rune R Jönsson Erik G EG Kirsch Peter P Kłoszewska Iwona I Lagerberg Trine Vik TV Landrø Nils Inge NI Le Hellard Stephanie S Lesch Klaus-Peter KP Maglanoc Luigi A LA Malt Ulrik F UF Mecocci Patrizia P Melle Ingrid I Meyer-Lindenberg Andreas A Moberget Torgeir T Nordvik Jan Egil JE Nyberg Lars L Connell Kevin S O' KSO Oosterlaan Jaap J Papalino Marco M Papassotiropoulos Andreas A Pauli Paul P Pergola Giulio G Persson Karin K de Quervain Dominique D Reif Andreas A Rokicki Jaroslav J van Rooij Daan D Shadrin Alexey A AA Schmidt André A Schwarz Emanuel E Selbæk Geir G Soininen Hilkka H Sowa Piotr P Steen Vidar M VM Tsolaki Magda M Vellas Bruno B Wang Lei L Westman Eric E Ziegler Georg C GC Zink Mathias M Andreassen Ole A OA Westlye Lars T LT Kaufmann Tobias T
Nature communications 20200811 1
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a no ...[more]