Dataset Information

Determination of physiological parameters for endogenous glucose production in individuals using diurnal data.

ABSTRACT:

Background

Triple tracer meal experiments used to investigate organ glucose-insulin dynamics, such as endogenous glucose production (EGP) of the liver are labor intensive and expensive. A procedure was developed to obtain individual liver related parameters to describe EGP dynamics without the need for tracers.

Results

The development used an existing formula describing the EGP dynamics comprising 4 parameters defined from glucose, insulin and C-peptide dynamics arising from triple meal studies. The method employs a set of partial differential equations in order to estimate the parameters for EGP dynamics. Tracer-derived and simulated data sets were used to develop and test the procedure. The predicted EGP dynamics showed an overall mean R ² of 0.91.

Conclusions

In summary, a method was developed for predicting the hepatic EGP dynamics for healthy, pre-diabetic, and type 2 diabetic individuals without applying tracer experiments.

SUBMITTER: van Stee MF

PROVIDER: S-EPMC7422590 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Determination of physiological parameters for endogenous glucose production in individuals using diurnal data.

van Stee Mariël F MF Krishnan Shaji S Groen Albert K AK de Graaf Albert A AA

BMC biomedical engineering 20191115

<h4>Background</h4>Triple tracer meal experiments used to investigate organ glucose-insulin dynamics, such as endogenous glucose production (EGP) of the liver are labor intensive and expensive. A procedure was developed to obtain individual liver related parameters to describe EGP dynamics without the need for tracers.<h4>Results</h4>The development used an existing formula describing the EGP dynamics comprising 4 parameters defined from glucose, insulin and C-peptide dynamics arising from tripl ...[more]

PMID: 32903378

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Dataset Information

Determination of physiological parameters for endogenous glucose production in individuals using diurnal data.

Background

Results

Conclusions

Publications

Determination of physiological parameters for endogenous glucose production in individuals using diurnal data.

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