Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19.
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ABSTRACT:
SUBMITTER: Mi T
PROVIDER: S-EPMC7423023 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19.
Mi Tianxiong T Burgess Kevin K
ACS medicinal chemistry letters 20200810 9
Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. All these reports give a structural basis for the deceptively difficult problem of accurate peptidomimetic loop mimic design. ...[more]
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