Project description:To reveal genetic determinants of susceptibility to COVID-19 severity in the population and further explore potential immune-related factors, we performed a genome-wide association study on 284 confirmed COVID-19 patients (cases) and 95 healthy individuals (controls). We compared cases and controls of European (EUR) ancestry and African American (AFR) ancestry separately. To further exploring the linkage between HLA and COVID-19 severity, we applied fine-mapping analysis to dissect the HLA association with mild and severe cases.

2023-01-17 | GSE211972 | GEO

TCR Rep-Seq of COVID-19 affected individuals

Project description:5'RACE-based TCR repertoire sequencing from peripheral blood

2024-09-26 | E-MTAB-13593 | biostudies-arrayexpress

Consensus on the Management of the COPD Patient in the COVID-19 Setting: COPD Forum Working Group.

Project description: Not available

| S-EPMC9116041 | biostudies-literature

Unresolved Immune Dysfunction is Lethal in Both COVID-19 and non-COVID-19 Sepsis

Project description:In this prospective observational cohort study, we found transcriptional evidence that persistent immune dysfunction was associated with 28-day mortality in both COVID-19 and non-COVID-19 septic patients. COVID-19 patients had an early antiviral response but became indistinguishable on a gene expression level from non-COVID-19 sepsis patients a week later. Early treatment of COVID-19 and non-COVID-19 sepsis ICU patients should focus on pathogen control, but both patient groups also require novel immunomodulatory treatments, particularly later during ICU hospitalization, independent of admission diagnosis. Some T1 samples were uploaded in GSE185263 and were not re-uploaded in this series.

2023-03-24 | GSE222393 | GEO

Dysregulation of COVID-19 related gene expression in the COPD lung.

Project description: Not available

| S-EPMC8164067 | biostudies-literature

COVID-19 Outbreak

Project description:COVID-19 Outbreak

| PRJNA615625 | ENA

covid-19 study

Project description:covid-19 study

| PRJEB43387 | ENA