Browse
Submit Data
Databases
API
Help

Dataset Information

28 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

High-acuity vision from retinal image motion.

ABSTRACT: A mathematical model and a possible neural mechanism are proposed to account for how fixational drift motion in the retina confers a benefit for the discrimination of high-acuity targets. We show that by simultaneously estimating object shape and eye motion, neurons in visual cortex can compute a higher quality representation of an object by averaging out non-uniformities in the retinal sampling lattice. The model proposes that this is accomplished by two separate populations of cortical neurons - one providing a representation of object shape and another representing eye position or motion - which are coupled through specific multiplicative connections. Combined with recent experimental findings, our model suggests that the visual system may utilize principles not unlike those used in computational imaging for achieving "super-resolution" via camera motion.

SUBMITTER: Anderson AG

PROVIDER: S-EPMC7424138 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

High-acuity vision from retinal image motion.

Anderson Alexander G AG Ratnam Kavitha K Roorda Austin A Olshausen Bruno A BA

Journal of vision 20200701 7

A mathematical model and a possible neural mechanism are proposed to account for how fixational drift motion in the retina confers a benefit for the discrimination of high-acuity targets. We show that by simultaneously estimating object shape and eye motion, neurons in visual cortex can compute a higher quality representation of an object by averaging out non-uniformities in the retinal sampling lattice. The model proposes that this is accomplished by two separate populations of cortical neurons ...[more]

PMID: 32735342

Similar Datasets

Benefits of retinal image motion at the limits of spatial vision.

Project description:Even during fixation, our eyes are constantly in motion, creating an ever-changing signal in each photoreceptor. Neuronal processes can exploit such transient signals to serve spatial vision, but it is not known how our finest visual acuity-one that we use for deciphering small letters or identifying distant faces and objects-is maintained when confronted with such change. We used an adaptive optics scanning laser ophthalmoscope to precisely control the spatiotemporal input on a photoreceptor scale in human observers during a visual discrimination task under conditions with habitual, cancelled or otherwise manipulated retinal image motion. We found that when stimuli moved, acuities were about 25% better than when no motion occurred, regardless of whether that motion was self-induced, a playback of similar motion, or an external simulation. We argue that in our particular experimental condition, the visual system is able to synthesize a higher resolution percept from multiple views of a poorly resolved image, a hypothesis that might extend the current understanding of how fixational eye motion serves high acuity vision.

| S-EPMC5283083 | biostudies-literature

Global Jitter Motion of the Retinal Image Dynamically Alters the Receptive Field Properties of Retinal Ganglion Cells.

Project description:Fixational eye movements induce aperiodic motion of the retinal image. However, it is not yet fully understood how fixational eye movements affect retinal information processing. Here we show that global jitter motion, simulating the image motion during fixation, alters the spatiotemporal receptive field properties of retinal ganglion cells. Using multi-electrode and whole-cell recording techniques, we investigated light-evoked responses from ganglion cells in the isolated goldfish retina. Ganglion cells were classified into six groups based on the filtering property of light stimulus, the membrane properties, and the cell morphology. The spatiotemporal receptive field profiles of retinal ganglion cells were estimated by the reverse correlation method, where the dense noise stimulus was applied on the dark or random-dot background. We found that the jitter motion of the random-dot background elongated the receptive filed along the rostral-caudal axis and temporally sensitized in a specific group of ganglion cells: Fast-transient ganglion cells. At the newly emerged regions of the receptive field local light stimulation evoked excitatory postsynaptic currents with large amplitude and fast kinetics without changing the properties of inhibitory postsynaptic currents. Pharmacological experiments suggested two presynaptic mechanisms underlying the receptive field alteration: (i) electrical coupling between bipolar cells, which expands the receptive field in all directions; (ii) GABAergic presynaptic inhibition from amacrine cells, which reduces the dorsal and ventral regions of the expanded receptive field, resulting in elongation along the rostral-caudal axis. Our study demonstrates that the receptive field of Fast-transient ganglion cells is not static but dynamically altered depending on the visual inputs. The receptive field elongation during fixational eye movements may contribute to prompt firing to a target in the succeeding saccade.

| S-EPMC6753181 | biostudies-literature

A circuit suppressing retinal drive to the optokinetic system during fast image motion.

Project description:Optokinetic nystagmus (OKN) assists stabilization of the retinal image during head rotation. OKN is driven by ON direction selective retinal ganglion cells (ON DSGCs), which encode both the direction and speed of global retinal slip. The synaptic circuits responsible for the direction selectivity of ON DSGCs are well understood, but those sculpting their slow-speed preference remain enigmatic. Here, we probe this mechanism in mouse retina through patch clamp recordings, functional imaging, genetic manipulation, and electron microscopic reconstructions. We confirm earlier evidence that feedforward glycinergic inhibition is the main suppressor of ON DSGC responses to fast motion, and reveal the source for this inhibition-the VGluT3 amacrine cell, a dual neurotransmitter, excitatory/inhibitory interneuron. Together, our results identify a role for VGluT3 cells in limiting the speed range of OKN. More broadly, they suggest VGluT3 cells shape the response of many retinal cell types to fast motion, suppressing it in some while enhancing it in others.

| S-EPMC10447436 | biostudies-literature

Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution.

Project description:Objective. Retinal degeneration involving progressive deterioration and loss of function of photoreceptors is a major cause of permanent vision loss worldwide. Strategies to treat these incurable conditions incorporate retinal prostheses via electrically stimulating surviving retinal neurons with implanted devices in the eye, optogenetic therapy, and sonogenetic therapy. Existing challenges of these strategies include invasive manner, complex implantation surgeries, and risky gene therapy. Methods and Results. Here, we show that direct ultrasound stimulation on the retina can evoke neuron activities from the visual centers including the superior colliculus and the primary visual cortex (V1), in either normal-sighted or retinal degenerated blind rats in vivo. The neuron activities induced by the customized spherically focused 3.1 MHz ultrasound transducer have shown both good spatial resolution of 250 μm and temporal resolution of 5 Hz in the rat visual centers. An additional customized 4.4 MHz helical transducer was further implemented to generate a static stimulation pattern of letter forms. Conclusion. Our findings demonstrate that ultrasound stimulation of the retina in vivo is a safe and effective approach with high spatiotemporal resolution, indicating a promising future of ultrasound stimulation as a novel and noninvasive visual prosthesis for translational applications in blind patients.

| S-EPMC10521738 | biostudies-literature

Without low spatial frequencies, high resolution vision would be detrimental to motion perception.

Project description:A normally sighted person can see a grating of 30 cycles per degree or higher, but spatial frequencies needed for motion perception are much lower than that. It is unknown for natural images with a wide spectrum how all the visible spatial frequencies contribute to motion speed perception. In this work, we studied the effect of spatial frequency content on motion speed estimation for sequences of natural and stochastic pixel images by simulating different visual conditions, including normal vision, low vision (low-pass filtering), and complementary vision (high-pass filtering at the same cutoff frequencies of the corresponding low-vision conditions) conditions. Speed was computed using a biological motion energy-based computational model. In natural sequences, there was no difference in speed estimation error between normal vision and low vision conditions, but it was significantly higher for complementary vision conditions (containing only high-frequency components) at higher speeds. In stochastic sequences that had a flat frequency distribution, the error in normal vision condition was significantly larger compared with low vision conditions at high speeds. On the contrary, such a detrimental effect on speed estimation accuracy was not found for low spatial frequencies. The simulation results were consistent with the motion direction detection task performed by human observers viewing stochastic sequences. Together, these results (i) reiterate the importance of low frequencies in motion perception, and (ii) indicate that high frequencies may be detrimental for speed estimation when low frequency content is weak or not present.

| S-EPMC7463184 | biostudies-literature

Motion-Based Acuity Task: Full Visual Field Measurement of Shape and Motion Perception.

Project description:PurposeDamage of retinal representation of the visual field affects its local features and the spared, unaffected parts. Measurements of visual deficiencies in ophthalmological patients are separated for central (shape) or peripheral (motion and space perception) properties, and acuity tasks rely on stationary stimuli. We explored the benefit of measuring shape and motion perception simultaneously using a new motion-based acuity task.MethodsEight healthy control subjects, three patients with retinitis pigmentosa (RP; tunnel vision), and 2 patients with Stargardt disease (STGD) juvenile macular degeneration were included. To model the peripheral loss, we narrowed the visual field in controls to 10 degrees. Negative and positive contrast of motion signals were tested in random-dot kinematograms (RDKs), where shapes were separated from the background by the motion of dots based on coherence, direction, or velocity. The task was to distinguish a circle from an ellipse. The difficulty of the task increased as ellipse became more circular until reaching the acuity limit.ResultsHigh velocity, negative contrast was more difficult for all, and for patients with STGD, it was too difficult to participate. A slower velocity improved acuity for all participants.ConclusionsProposed acuity testing not only allows for the full assessment of vision but also advances the capability of standard testing with the potential to detect spare visual functions.Translational relevanceThe motion-based acuity task might be a practical tool for assessing vision loss and revealing undetected, undamaged, or strengthened properties of the injured visual system by standard testing, as suggested here for two patients with STGD and three patients with RP.

| S-EPMC7794260 | biostudies-literature

Stereo Vision-Based High Dynamic Range Imaging Using Differently-Exposed Image Pair.

Project description:In this paper, a high dynamic range (HDR) imaging method based on the stereo vision system is presented. The proposed method uses differently exposed low dynamic range (LDR) images captured from a stereo camera. The stereo LDR images are first converted to initial stereo HDR images using the inverse camera response function estimated from the LDR images. However, due to the limited dynamic range of the stereo LDR camera, the radiance values in under/over-exposed regions of the initial main-view (MV) HDR image can be lost. To restore these radiance values, the proposed stereo matching and hole-filling algorithms are applied to the stereo HDR images. Specifically, the auxiliary-view (AV) HDR image is warped by using the estimated disparity between initial the stereo HDR images and then effective hole-filling is applied to the warped AV HDR image. To reconstruct the final MV HDR, the warped and hole-filled AV HDR image is fused with the initial MV HDR image using the weight map. The experimental results demonstrate objectively and subjectively that the proposed stereo HDR imaging method provides better performance compared to the conventional method.

| S-EPMC5539793 | biostudies-other

Reading Acuity as a Predictor of Low-Vision Reading Performance.

Project description:PurposeMost people with low vision experience difficulty with reading. Reading assessment can provide guidance for prescription of reading aids and strategies for reading rehabilitation. Here we investigate the effectiveness of letter acuity (LA) and reading acuity (RA) as predictors of low-vision reading performance.MethodsLow-vision subjects (n = 58), young control subjects (n = 52), and older control subjects (n = 14) participated in this study. The low-vision subjects were separated into a Macular group (n = 30) and a Nonmacular group (n = 28) based on whether the diagnoses primarily affected the macular area. LA was measured with the Lighthouse Distance Visual Acuity Chart and RA with the MNREAD Acuity Chart. Reading speeds were obtained across a range of print sizes from the MNREAD test. The MNREAD data were used to estimate required print sizes for three functionally important types of reading for each subject: spot reading (40 words/min [wpm]), fluent reading (80 wpm), and critical print size (required to achieve maximum reading speed).ResultsFor equal values of LA, the Macular group had significantly worse RA than the Nonmacular group. The differences between vision groups, as well as individual variations within groups, were largely explained by the differences in RA. RA is a better predictor than LA for spot reading size, fluent reading size, and critical print size.ConclusionsRA may provide more accurate assessment of reading performance than LA for purposes of low-vision reading rehabilitation.

| S-EPMC6181187 | biostudies-literature

Programmable ferroelectric bionic vision hardware with selective attention for high-precision image classification.

Project description:Selective attention is an efficient processing strategy to allocate computational resources for pivotal optical information. However, the hardware implementation of selective visual attention in conventional intelligent system is usually bulky and complex along with high computational cost. Here, programmable ferroelectric bionic vision hardware to emulate the selective attention is proposed. The tunneling effect of photogenerated carriers are controlled by dynamic variation of energy barrier, enabling the modulation of memory strength from 9.1% to 47.1% without peripheral storage unit. The molecular polarization of ferroelectric P(VDF-TrFE) layer enables a single device not only multiple nonvolatile states but also the implementation of selective attention. With these ferroelectric devices are arrayed together, UV light information can be selectively recorded and suppressed the with high current decibel level. Furthermore, the device with positive polarization exhibits high wavelength dependence in the image attention processing, and the fabricated ferroelectric sensory network exhibits high accuracy of 95.7% in the pattern classification for multi-wavelength images. This study can enrich the neuromorphic functions of bioinspired sensing devices and pave the way for profound implications of future bioinspired optoelectronics.

| S-EPMC9669032 | biostudies-literature

Perception of biological motion without local image motion.

Project description:A vivid perception of the moving form of a human figure can be obtained from a few moving light points on the joints of the body. This is known as biological motion perception. It is commonly believed that the perception of biological motion rests on image motion signals. Curiously, however, some patients with lesions to motion processing areas of the dorsal stream are severely impaired in image motion perception but can easily perceive biological motion. Here we describe a biological motion stimulus based on a limited lifetime technique that tests the perception of a moving human figure in the absence of local image motion. We find that subjects can spontaneously recognize a moving human figure in displays without local image motion. Their performance is very similar to that for classic point-light displays. We also find that tasks involving the discrimination of walking direction or the coherence of a walking figure can be performed in the absence of image motion. Thus, although image motion may generally aid processes such as segmenting figure from background, we propose that it is not the basis for the precept of biological motion. Rather, we suggest biological motion is derived from dynamic form information on body posture evolving over time.

| S-EPMC122827 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data