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Characteristics and outcomes of preterm neonates according to number of doses of surfactant received.


ABSTRACT: OBJECTIVES:To identify characteristics and outcomes of infants who received multiple doses of surfactant vs those who received one dose or none. STUDY DESIGN:In this retrospective study, we included neonates of 22-28 weeks' gestation admitted to NICUs in the Canadian Neonatal Network. Patients were divided into three groups: no surfactant, single dose, and multiple doses. The primary outcome was a composite of mortality or any of the major morbidities, including severe neurological injury, bronchopulmonary dysplasia, or ?stage 3 retinopathy of prematurity. RESULTS:Of 8024 eligible neonates, 2461 (31%) did not receive surfactant, 3545 (44%) received one dose, and 2018 (25%) received >1 dose. Receiving one or more doses of surfactant was associated with significantly higher adjusted odds of mortality or major morbidities in a dose-dependent manner. CONCLUSIONS:Receiving one or more doses of surfactant was associated with adverse neonatal outcomes. Receipt of more than one dose may reflect underlying severe lung immaturity.

SUBMITTER: Coshal H 

PROVIDER: S-EPMC7424238 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Characteristics and outcomes of preterm neonates according to number of doses of surfactant received.

Coshal Hanita H   Mukerji Amit A   Lemyre Brigitte B   Ng Eugene H EH   Alvaro Ruben R   Ethier Guillaume G   Yoon Eugene W EW   Beltempo Marc M   Shah Prakesh S PS  

Journal of perinatology : official journal of the California Perinatal Association 20200813 1


<h4>Objectives</h4>To identify characteristics and outcomes of infants who received multiple doses of surfactant vs those who received one dose or none.<h4>Study design</h4>In this retrospective study, we included neonates of 22-28 weeks' gestation admitted to NICUs in the Canadian Neonatal Network. Patients were divided into three groups: no surfactant, single dose, and multiple doses. The primary outcome was a composite of mortality or any of the major morbidities, including severe neurologica  ...[more]

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