Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC7424762 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Yu Yifan Y Niccoli Teresa T Ren Ziyu Z Woodling Nathaniel S NS Aleyakpo Benjamin B Szabadkai Gyorgy G Partridge Linda L
Human molecular genetics 20200801 14
Alzheimer's disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in Aβ42 production and turnover, but whether it plays a direct role in modulating Aβ42 toxicity remains unclear. We found that increased expression of the Drosophila PICALM orthologue lap could rescue Aβ42 toxicity in an adult-onset model of AD, without affecting Aβ42 level. Imbalances in the gluta ...[more]