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Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus.

ABSTRACT: Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± 5.1%) and nephropathy (24.1 ± 3.9%, 24.6 ± 4.2%, 28.5 ± 6.1%, 31.3 ± 5.7%, 37.8 ± 2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications.

SUBMITTER: Kobayashi Y

PROVIDER: S-EPMC7424782 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus.

Kobayashi Yuka Y Suzuki Ryo R Yasukawa Keiko K Oba Koji K Yamauchi Toshimasa T Yatomi Yutaka Y Kadowaki Takashi T

Metabolism open 20200314

Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± ...[more]

PMID: 32812907

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