PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD).

ABSTRACT: Objective:A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored. Study design:A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD. The potential pathogenic role of Pin1 was evaluated by enzyme-linked immunosorbent (ELISA) assay and single nucleotide polymorphism (SNP) sequencing. Results:ELISA determined a six-time higher concentration of plasma Pin1 compared to our previous data. Nine PIN1 SNPs were sequenced and classified according to their NAFLD-pathogenic risks, suggesting that rs2233678 and rs2287839 may be the most important genotypes that result in Pin1 overexpression and NAFLD development. Conclusion:In summary, this work explores a novel basis for early-onset NAFLD and highlights that elevated plasma Pin1 may predict NAFLD risk at early stage. Hypothetically, inhibiting Pin1 may benefit NAFLD prevention in the future.

SUBMITTER: Wang JZ 

PROVIDER: S-EPMC7424804 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature