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PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD).

ABSTRACT: Objective:A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored. Study design:A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD. The potential pathogenic role of Pin1 was evaluated by enzyme-linked immunosorbent (ELISA) assay and single nucleotide polymorphism (SNP) sequencing. Results:ELISA determined a six-time higher concentration of plasma Pin1 compared to our previous data. Nine PIN1 SNPs were sequenced and classified according to their NAFLD-pathogenic risks, suggesting that rs2233678 and rs2287839 may be the most important genotypes that result in Pin1 overexpression and NAFLD development. Conclusion:In summary, this work explores a novel basis for early-onset NAFLD and highlights that elevated plasma Pin1 may predict NAFLD risk at early stage. Hypothetically, inhibiting Pin1 may benefit NAFLD prevention in the future.

SUBMITTER: Wang JZ

PROVIDER: S-EPMC7424804 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD).

Wang Jing-Zhang JZ Zhang Yu-Hua YH Bai Jing J Liu Yan-Wei YW Du Wen-Tao WT

Metabolism open 20190806

<h4>Objective</h4>A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored.<h4>Study design</h4>A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD. The potential pathogenic role of Pin1 was evaluated by enzyme-linked immunosorbent (ELISA) assay and single nucleotide polymorphism (SNP) sequencing.<h4>Results</h4>ELISA determined a six-time higher concentration of plasma Pin1 compared to our previous data. Nine <i>PIN1</i> SNPs ...[more]

PMID: 32812930

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