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Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity.


ABSTRACT: The cytoplasmic polyadenylation element-binding (CPEB) protein family have demonstrated a crucial role for establishing synaptic plasticity and memory in model organisms. In this review, we outline evidence for CPEB3 as a crucial regulator of learning and memory, citing evidence from behavioral, electrophysiological and morphological studies. Subsequently, the regulatory role of CPEB3 is addressed in the context of the plasticity-related proteins, including AMPA and NMDA receptor subunits, actin, and the synaptic scaffolding protein PSD95. Finally, we delve into some of the more well-studied molecular mechanisms that guide the functionality of this dynamic regulator both during synaptic stimulation and in its basal state, including a variety of upstream regulators, post-translational modifications, and important structural domains that confer the unique properties of CPEB3. Collectively, this review offers a comprehensive view of the regulatory layers that allow a pathway for CPEB3's maintenance of translational control that guides the necessary protein changes required for the establishment and maintenance of lasting synaptic plasticity and ultimately, long term learning and memory.

SUBMITTER: Qu WR 

PROVIDER: S-EPMC7425470 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity.

Qu Wen Rui WR   Sun Qi Han QH   Liu Qian Qian QQ   Jin Hong Juan HJ   Cui Ran Ji RJ   Yang Wei W   Song De Biao B   Li Bing Jin BJ  

Aging 20200702 14


The cytoplasmic polyadenylation element-binding (CPEB) protein family have demonstrated a crucial role for establishing synaptic plasticity and memory in model organisms. In this review, we outline evidence for CPEB3 as a crucial regulator of learning and memory, citing evidence from behavioral, electrophysiological and morphological studies. Subsequently, the regulatory role of CPEB3 is addressed in the context of the plasticity-related proteins, including AMPA and NMDA receptor subunits, actin  ...[more]

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