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Highs and lows: Genetic susceptibility to daily events.

ABSTRACT: Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person's reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susceptibility factor for daily events. Participants (N = 326, 77% female, mean age = 25, range = 17-36) completed smartphone questionnaires four times a day over four to five days, measuring stressors, uplifts, positive and negative affect. Affect was predicted from environment valence in the previous hour on a within-person level using three-level autoregressive linear mixed models. The 5-HTTLPR fulfilled all criteria of a differential susceptibility factor: Positive affect in carriers of the short allele (S) was less reactive to both uplifts and stressors, compared to homozygous carriers of the long allele (L/L). This pattern might reflect relative affective inflexibility in S-allele carriers. Our study provides insight into the serotonin system's general role in susceptibility and highlights the need to assess the whole spectrum of naturalistic experiences.

SUBMITTER: Sicorello M

PROVIDER: S-EPMC7425846 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Highs and lows: Genetic susceptibility to daily events.

Sicorello Maurizio M Dieckmann Linda L Moser Dirk D Lux Vanessa V Luhmann Maike M Neubauer Andreas B AB Schlotz Wolff W Kumsta Robert R

PloS one 20200813 8

Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person's reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susce ...[more]

PMID: 32790782

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Highs and lows: Genetic susceptibility to daily events.

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Highs and lows: Genetic susceptibility to daily events.

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