Ontology highlight
ABSTRACT:
SUBMITTER: Chu W
PROVIDER: S-EPMC7426018 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Chu Wanghuan W Li Runze R Liu Jingyuan J Reimherr Matthew M
The annals of applied statistics 20200301 1
Motivated by an empirical analysis of data from a genome-wide association study on obesity, measured by the body mass index (BMI), we propose a two-step gene-detection procedure for generalized varying coefficient mixed-effects models with ultrahigh dimensional covariates. The proposed procedure selects significant single nucleotide polymorphisms (SNPs) impacting the mean BMI trend, some of which have already been biologically proven to be "fat genes." The method also discovers SNPs that signifi ...[more]