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Prevalence of obstructive sleep apnea in patients with peripheral arterial diseases.

ABSTRACT: BACKGROUND:The presence of obstructive sleep apnea (OSA), a novel cardiovascular risk factor, contributes to the development of peripheral arterial diseases (PAD). There is a lack of data showing how often these diseases coexist. AIMS:The aim of the study was to determine the prevalence of OSA in the population of patients with PAD. METHODS:Patients previously qualified for the first revascularization due to PAD were included in the study. All patients underwent an overnight sleep study to detect OSA. Diagnosis of OSA was made when the apnea-hypopnea index (AHI) was ?5 per hour. RESULTS:From 141 patients (60% men, age 69.6 ± 9.5 years), OSA was diagnosed in 68 patients (48%). OSA occurred in mild form (5 ? AHI < 15/h) in 39 cases (28%), in moderate form (15 ? AHI < 30/h) in 21 cases (15%), and in severe form (AHI ? 30/h) in 8 cases (6%). Patients without OSA had significantly lower body mass index (BMI; 26.9 ± 5.5 vs. 27.7 ± 5.3 kg/m2, p = 0.01) and lower hip circumference (97.4 ± 11.7 vs. 98.7 ± 7.4, p = 0.04). There were no differences in the distribution of other investigated cardiovascular risk factors and diseases between these groups. There were no significant differences in OSA distribution or its severity between patients with lower extremity artery disease and carotid artery disease. CONCLUSIONS:The prevalence of OSA in patients with PAD is very high, affecting nearly half of the studied population.

SUBMITTER: Szymanski FM

PROVIDER: S-EPMC7426286 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Prevalence of obstructive sleep apnea in patients with peripheral arterial diseases.

Szymanski Filip M FM Gorko Dariusz D Platek Anna E AE Ostrowski Tomasz T Celejewski Krzysztof K Chudzinski Witold W Szymanska Anna A Stepkowski Kamil K Rys-Czaporowska Anna A Semczuk-Kaczmarek Karolina K Galazka Zbigniew Z Filipiak Krzysztof J KJ

Sleep & breathing = Schlaf & Atmung 20191114 3

<h4>Background</h4>The presence of obstructive sleep apnea (OSA), a novel cardiovascular risk factor, contributes to the development of peripheral arterial diseases (PAD). There is a lack of data showing how often these diseases coexist.<h4>Aims</h4>The aim of the study was to determine the prevalence of OSA in the population of patients with PAD.<h4>Methods</h4>Patients previously qualified for the first revascularization due to PAD were included in the study. All patients underwent an overnigh ...[more]

PMID: 31728764

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Project description:BackgroundObstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) is an important health concern. The prevalence of OSA with ED is increasing, which significantly affects the quality of life and work efficiency of patients. However, the mechanism underlying the comorbidity of these two diseases remains unclear.Objectives(1) Investigate the prevalence of OSA with ED; (2) analyze the correlation between OSA and ED; and (3) explore the treatment response to and possible mechanism of uvulapalatopharyngoplasty (UPPP) in patients with OSA and ED. This study aims to provide a theoretical basis for the clinical diagnosis and comprehensive treatment of OSA with ED and improve prevention and treatment strategies.Materials and methodsIn total, 135 subjects were enrolled in the study. Clinical data, polysomnography, the ESS score, Beck anxiety score, Beck depression score, IIEF-5 score and ASEX score were recorded before UPPP and 6 months after UPPP. Sex hormones were measured for all subjects using a Roche electrochemiluminescence analyzer.ResultThe prevalence of OSA with ED was 64.52%, and the prevalence of severe OSA with ED was 73.02%. The prevalence of OSA with ED increased with age, BMI and apnea-hypopnea index (AHI) value. Among polysomnography indicators, minimum oxygen saturation and average oxygen saturation may predict the occurrence of OSA with ED. Improving the patient's anxiety and depression is very important for treating OSA with ED. Sex hormone levels were not significantly correlated with the occurrence of OSA with ED.ConclusionED is a common symptom of OSA patients. This study showed that sex hormone levels in OSA patients with ED were not significantly correlated with the condition, but further investigation of this relationship is worthwhile. It is recommended that the free and combined types of sex hormones be further distinguished during testing because the free type is the active form. UPPP surgical treatment is effective for OSA with ED, and its possible mechanism is protection of the peripheral nerves of the sex organs by improving nighttime hypoxia and arousal.

Dataset Information

Prevalence of obstructive sleep apnea in patients with peripheral arterial diseases.

Publications

Prevalence of obstructive sleep apnea in patients with peripheral arterial diseases.

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